Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88
نویسندگان
چکیده
منابع مشابه
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo.
To participate as co-receptor in growth factor signaling, heparan sulfate must have specific structural features. Recent studies show that when the levels of 6-O-sulfation of heparan sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases (Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and hepatocyte growth factor-mediated signa...
متن کاملPI-88 and novel heparan sulfate mimetics inhibit angiogenesis.
The heparan sulfate (HS) mimetic PI-88 is a promising inhibitor of tumor growth and metastasis expected to commence phase III clinical evaluation in 2007 as an adjuvant therapy for postresection hepatocellular carcinoma. Its anticancer properties are attributed to inhibition of angiogenesis via antagonism of the interactions of angiogenic growth factors and their receptors with HS. It is also a...
متن کاملHSulf-1 inhibits angiogenesis and tumorigenesis in vivo.
We previously identified HSulf-1 as a down-regulated gene in several tumor types including ovarian, breast, and hepatocellular carcinomas. Loss of HSulf-1, which selectively removes 6-O-sulfate from heparan sulfate, up-regulates heparin-binding growth factor signaling and confers resistance to chemotherapy-induced apoptosis. Here we report that HSulf-1 expression in MDA-MB-468 breast carcinoma ...
متن کاملTITLE: Evaluation of extracellular endosulfatase HSULF-2 in breast cancer Cell WNT signaling and its inhibition by a sulfate ester derivative of synthetic antioxidant. PRINCIPAL INVESTIGATOR:
TITLE: Evaluation of extracellular endosulfatase HSULF-2 in breast cancer Cell WNT signaling and its inhibition by a sulfate ester derivative of synthetic antioxidant. The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. P...
متن کاملhSulf-1 Gene Exhibits Anticancer Efficacy through Negatively Regulating VEGFR-2 Signaling in Human Cancers
BACKGROUND Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell proliferation. But hSulf-1 function is more complicated, and its molecular mechanism has not been well known. PRINCIPAL FINDINGS To further in...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2009
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwp159